approach

Making the latest scientific advances in
longevity accessible and achievable for all

Novos is the scientific leader in longevity with a mission to add a billion years of life to humanity by making the latest scientific advances in longevity accessible and achievable by all. Based on pioneering research, our longevity solutions are designed to help you slow down aging during your longevity journey. We're committed to providing scientific evidence that empowers you to take control of your healthspan and lifespan.

We created NOVOS products in collaboration with leading
scientists and medical doctors, and many of these experts are
now part of our advisory board. We developed our synergistic
blend of 12 ingredients for Core and the best quality NMN for
Boost based on proven scientific evidence. The ingredients we
The choices for Novos formulations are based on the following criteria:

01 They have the ability to impact at least one, and ideally multiple, mechanisms of aging simultaneously

These aging mechanisms are epigenetic alterations, loss of proteostasis (protein accumulation inside and outside our cells), cellular senescence, mitochondrial dysfunction, genomic instability, deregulated nutrient sensing, altered intercellular communication (e.g., inflammation/inflammaging), and so on.

Ideally, each ingredient influences multiple aging mechanisms. For example, glycine has epigenetic effects but can also act as a chaperone, protecting proteins and helping the body deal with protein accumulation (which is one of the reasons why we age). Glucosamine can improve mitochondrial health by inducing mitochondrial biogenesis, but can also support autophagy. In this way, combining such ingredients enables synergistic effects on the aging process.

02 They have been able to extend lifespan in various animal models, hinting at conserved evolutionary pathways

Ideally, the ingredients extend lifespan not in just one animal model, but in different species. If the compound extends lifespan in various different species, it’s more likely it will also work in humans. Examples are alpha-ketoglutarate (AKG), which extends lifespan in C elegans, fruit flies, and mice. Glycine can extend lifespan in C elegans and fruit flies, but also in mice and rats.

03 They are associated with reduced risk of different aging-related processes and outcomes in humans and animals, indicating that they act on the underlying aging process

A substance that can improve various aging-related symptoms, for example by slowing down brain aging, improving heart health, and boosting metabolism, is likely to act on the underlying mechanism that unites all these aging-related afflictions. For example, pterostilbene can contribute to healthy brain aging and support a healthy sugar metabolism, while also improving cardiovascular function and contributing to a healthy inflammatory response.

04 They are associated with reduced risk of mortality in humans

Ideally, studies also show an association between reduced mortality in humans that take the supplement on a regular basis. For example, studies in the US and Europe have shown that glucosamine was only one of the few supplements associated with reduced mortality. People who took glucosamine also had significantly healthier hearts and blood vessels.

05 They are nature-based, found in food or human biology, but levels decline with age

Ideally, they are nature-based and have been present alongside human evolution, and not novel man-made, lab-made molecules. All of the ingredients in NOVOS’ formulations are found in nature.

Ideally, the substances are found in our bodies, and their levels decline with age. This hints at their safety and to the fact that their declining levels could play a role in accelerating (or contributing to) ageing. Examples of molecules present at higher levels in young tissues but declining with ageing are alpha-ketoglutarate and glycine.

06 They have a very low side effect profile

The substances are known to cause very little side effects (if any), and no serious side effects, even at much greater dosages.

References

López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. The hallmarks of aging. Cell. 2013 Jun 6;153(6):1194-217. doi: 10.1016/j.cell.2013.05.039. PMID: 23746838; PMCID: PMC3836174.
Teulière, J., Bernard, C., Corel, E. et al. Network analyses unveil ageing-associated pathways evolutionarily conserved from fungi to animals. GeroScience 45, 1059–1080 (2023). https://doi.org/10.1007/s11357-022-00704-2

Dr. George Church, PhD

“I see NOVOS as inspiring — they approach aging as a complex phenomenon, aiming at all pathways and hallmarks of aging simultaneously.”

Harvard Medical School & MIT Professor

Dr. Pamela Maher, PhD

“What really impressed me about NOVOS was the comprehensiveness of their analysis of aging research to design their product.”

Salk Institute & University of British Columbia

Dr. J. Pedro Magalhães, PhD

“NOVOS has been using a novel science-based approach for developing its formulation. [They are] a leader in the longevity space.”

Harvard Medical School

Dr. Robert Lufkin, MD

“It’s the rigorously-researched, science-backed formulations that set NOVOS apart in the longevity supplements space.”

USC School of Medicine Professor

We've got you covered

Go beyond the longevity solutions and get an insider view of the latest breakthrough science. NOVOS is a Public Benefit Corporation that provides science-based tips, actionable guidance, and expert-backed tools to the public for free.

Artikeln har lagts till i varukorgen

Making the latest scientific advances in
longevity accessible and achievable for all

01

They have the ability to impact at least one, and ideally multiple, mechanisms of aging simultaneously

02

They have been able to extend lifespan in various animal models, hinting at conserved evolutionary pathways

03

They are associated with reduced risk of different aging-related processes and outcomes in humans and animals, indicating that they act on the underlying aging process

04

They are associated with reduced risk of mortality in humans

05

They are nature-based, found in food or human biology, but levels decline with age

Ideally, they are nature-based and have been present alongside human evolution, and not novel man-made, lab-made molecules. All of the ingredients in NOVOS’ formulations are found in nature.

06

They have a very low side effect profile

The substances are known to cause very little side effects (if any), and no serious side effects, even at much greater dosages.

References

Dr. George Church, PhD

Dr. Pamela Maher, PhD

Dr. J. Pedro Magalhães, PhD

Dr. Robert Lufkin, MD

We've got you covered

Land/Region

Land/Region

Making the latest scientific advances inlongevity accessible and achievable for all

01

They have the ability to impact at least one, and ideally multiple, mechanisms of aging simultaneously

02

They have been able to extend lifespan in various animal models, hinting at conserved evolutionary pathways

03

They are associated with reduced risk of different aging-related processes and outcomes in humans and animals, indicating that they act on the underlying aging process

04

They are associated with reduced risk of mortality in humans

05

They are nature-based, found in food or human biology, but levels decline with age

Ideally, they are nature-based and have been present alongside human evolution, and not novel man-made, lab-made molecules. All of the ingredients in NOVOS’ formulations are found in nature.

06

They have a very low side effect profile

The substances are known to cause very little side effects (if any), and no serious side effects, even at much greater dosages.

References

Dr. George Church, PhD

Dr. Pamela Maher, PhD

Dr. J. Pedro Magalhães, PhD

Dr. Robert Lufkin, MD

We've got you covered

Making the latest scientific advances in
longevity accessible and achievable for all